Liga MX leader Tigres hits the road for a Saturday match at last-place San Luis, before a long trek up to Seattle for their CCL clash, in which they'll try to defend the 1-0 advantage garnered on Wednesday night over the Sounders. UANL is unbeaten in nine league games, including six wins. Star forward Emanuel Villa has a league-best eight goals, but he is expected to miss out due to injury.
Two-time defending CONCACAF champion Monterrey returns from its big win in Quetzaltenango over Xelaju for an important league encounter at home on Saturday against Leon. The result will be crucial for both teams, as last season's semifinalist Leon sits in 16th place after nine matches, two spots behind the Rayados. With a win, Monterrey could feasibly climb all the way to eighth.
Xelaju, will also be looking to get back on track in Guatemalan play after three straight losses in the Liga Mayor. The 10th place Super Chivos are just three points back of fourth, but face a difficult home date with leader Comunicaciones. The Cremas, apart from being undefeated in eight Clausura matches, have yet to give up a goal this season.
Back in Mexico, Santos is looking for a third straight Liga MX win, when it hosts 15th place Atlante on Saturday in Torreon. In 17 Mexican league short tournament meetings between them, the 2011/12 CCL runner-up has registered 11 wins. The Guerreros, who dropped a 1-0 decision at the Houston Dynamo on Tuesday, can climb to as high as fourth with a win and other favorable results.
Finally, after a scoreless tie in CCL play on Thursday, Herediano has the weekend off in Costa Rica, before traveling to the United States to face the LA Galaxy once again.