According to the La Liga president Raul Pinto, Ramirez decided to step down due to health and personal considerations.
Pinto said that the search for new coach will start immediately, especially in consideration of the fact that the Torneo Verano commences in just over a week. He did not speculate on any possible candidates for the position.
Ramirez, a legend of Costa Rican football, won four titles in five tournaments as La Liga's head coach, including the recently completed 2012 Apertura. Alajuelense overcame Herdiano 3-2 on aggregate in the two-leg final.
He guided the 28-time domestic champion to appearances in the last two editions of the CONCACAF Champions League (2011/12, 2012/13), compiling a record of six wins, one draw and three losses.
The 48-year-old was an outstanding performer for two decades in the Costa Rican league and spent the majority of his career with Alajuelense and Saprissa. The midfielder also played for Costa Rica at the 1990 World Cup finals in Italy, starting in the historic wins over Sweden and Scotland.