Antigua, which advanced to the semifinal round of 2014 CONCACAF World Cup Qualifying before being eliminated in October, came out of the gate with all cylinders firing.
In the 2nd minute, Quinton Griffith hammered a 25-yard free kick against the post, leaving the goal to wobble in its wake.
Peter Byers broke through 15 minutes later, giving the home side a 1-0 lead with a shot from 18-yards out that eluded Dominican goalkeeper Miguel Lloyd.
As the game went on, the Dominican Republic started to settle and develop a rhythm, but it could not pierce the Antiguan backline.
The Benna Boys, though, constantly threatened to double their lead. Tamorley Thomas should have done just that, but after breaking free towards goal, he shot tamely.
Antigua came out of the break in a buoyant mood and continued to play some enterprising football. Several near misses resulted as the visitors made the decision to advance their attacks down the right side of the pitch.
Domingo Peralta thought he equalized in the 55th minute, only to have a goal disallowed for offside.
The Dominican Republic was rewarded for its persistence in the 74th minute thanks to a Cesar Peralta free kick, making the score 1-1.
Second-half substitute Erik Lopez made his presence felt, setting up Faña Farias with a delightful through ball that the 25-year-old hit past goalkeeper Molvin James with a minute left in regulation time. It was Fana Farias' seventh goal in this year's competition.
Antigua had one last chance, but the duo of Byers and Randolph Burton could not place a loose ball, which slipped out of Lloyd's hands, into an open net.
The Dominican Republic's next outing is on Sunday against neighbor Haiti, while Antigua will meet Trinidad & Tobago later that same day.